Drug Information

Drug General Information
Drug ID
D0G5TU
Former ID
DIB003749
Drug Name
LESOPITRON DIHYDROCHLORIDE
Synonyms
Lesopitran; Lesopitran); E-4424; Lesopitron dihydrochloride < Rec INNM >; 2-[4-[4-(4-Chloropyrazol-1-yl)butyl]piperazin-1-yl]pyrimidine dihydrochloride
Drug Type
Small molecular drug
Indication Mood disorder [ICD10:F30-F39] Discontinued in Phase 2 [544898]
Company
Esteve Group
Formula
C15H21ClN6
Canonical SMILES
C1CN(CCN1CCCCN2C=C(C=N2)Cl)C3=NC=CC=N3
InChI
1S/C15H21ClN6/c16-14-12-19-22(13-14)7-2-1-6-20-8-10-21(11-9-20)15-17-4-3-5-18-15/h3-5,12-13H,1-2,6-11H2
InChIKey
AHCPKWJUALHOPH-UHFFFAOYSA-N
CAS Number
CAS 132449-46-8
PubChem Compound ID
60813
PubChem Substance ID
8187070, 14777028, 43118152, 47583661, 48253853, 50350090, 57314127, 85210030, 104321707, 117465697, 127406012, 135026068, 136350337, 137147725, 139157594, 160692615, 162222358, 175426922, 179149816, 198940297, 225001374, 226596393
Target and Pathway
Target(s) 5-hydroxytryptamine 1A receptor Target Info Agonist [533618]
KEGG Pathway cAMP signaling pathway
Neuroactive ligand-receptor interaction
Serotonergic synapse
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
5HT1 type receptor mediated signaling pathway
Reactome Serotonin receptors
G alpha (i) signalling events
WikiPathways Serotonin HTR1 Group and FOS Pathway
SIDS Susceptibility Pathways
Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signaling
References
Ref 544898Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800001441)
Ref 533618Effect of acute administration of the 5-HT1A receptor ligand, lesopitron, on rat cortical 5-HT and dopamine turnover. Br J Pharmacol. 1994 Oct;113(2):425-30.

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