Drug Information

Drug General Information
Drug ID
D0G5DK
Former ID
DIB009640
Drug Name
ONO-1301
Drug Type
Small molecular drug
Indication Angina pectoris [ICD9: 413; ICD10:I20] Preclinical [539261], [545843]
Company
Ono Pharmaceutical Co Ltd
Formula
C26H24N2O4
InChI
InChI=1S/C26H24N2O4/c29-25(30)18-31-24-13-5-11-22-19(9-4-12-23(22)24)14-16-32-28-26(20-7-2-1-3-8-20)21-10-6-15-27-17-21/h1-3,5-11,13,15,17H,4,12,14,16,18H2,(H,29,30)/b28-26+
InChIKey
WBBLIRPKRKYMTD-BYCLXTJYSA-N
CAS Number
CAS 176391-41-6
PubChem Compound ID
6536812
PubChem Substance ID
7979799, 11643925, 14880733, 24724561, 29217610, 43183005, 79679720, 103460307, 114611047, 229759074
Target and Pathway
Target(s) Thromboxane-A synthase Target Info Agonist [531705]
BioCyc Pathway C20 prostanoid biosynthesis
KEGG Pathway Arachidonic acid metabolism
Metabolic pathways
Platelet activation
PathWhiz Pathway Arachidonic Acid Metabolism
WikiPathways Prostaglandin Synthesis and Regulation
Arachidonic acid metabolism
Phase 1 - Functionalization of compounds
Eicosanoid Synthesis
References
Ref 539261(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1964).
Ref 545843Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800005013)
Ref 531705A synthetic prostacyclin agonist with thromboxane synthase inhibitory activity, ONO-1301, protects myocardium from ischemia/reperfusion injury. Eur J Pharmacol. 2012 Jan 15;674(2-3):352-8.

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