Drug Information

Drug General Information
Drug ID
D0G3OY
Former ID
DIB020343
Drug Name
methylhistaprodifen
Synonyms
N-methylhistaprodifen
Drug Type
Small molecular drug
Indication Discovery agent Investigative [538718]
Formula
C21H25N3
InChI
InChI=1S/C21H25N3/c1-22-15-14-19-16-23-21(24-19)13-12-20(17-8-4-2-5-9-17)18-10-6-3-7-11-18/h2-11,16,20,22H,12-15H2,1H3,(H,23,24)
InChIKey
YMVWDVNGNLXSKR-UHFFFAOYSA-N
PubChem Compound ID
10403687
PubChem Substance ID
15420770, 42233767, 48105229, 48179746, 76301215, 85209174, 90341012, 92729720, 103171945, 135650593, 136352275
Target and Pathway
Target(s) Histamine H1 receptor Target Info Agonist [526569]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Inflammatory mediator regulation of TRP channels
PANTHER Pathway Histamine H1 receptor mediated signaling pathway
Reactome Histamine receptors
G alpha (q) signalling events
WikiPathways Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
IL-4 Signaling Pathway
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR ligand binding
GPCR downstream signaling
References
Ref 538718(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1205).
Ref 526569Multiple differences in agonist and antagonist pharmacology between human and guinea pig histamine H1-receptor. J Pharmacol Exp Ther. 2003 Jun;305(3):1104-15. Epub 2003 Mar 6.

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