Drug Information

Drug General Information
Drug ID
D0G3MH
Former ID
DIB014392
Drug Name
PNU-96391A
Synonyms
DS 121; (-)-DS-121; (-)-OSU-6162
Drug Type
Small molecular drug
Indication Substance dependence [ICD10:F10-F19] Terminated [532971]
Company
University of Gothenburg
Formula
C15H23NO2S
Canonical SMILES
S(=O)(=O)(c1cc([C@H]2CN(CCC2)CCC)ccc1)C
CAS Number
CAS 150336-90-6
PubChem Compound ID
22283003
Target and Pathway
Target(s) D(3) dopamine receptor Target Info Modulator [532971]
D(2) dopamine receptor Target Info Modulator [532971]
KEGG Pathway Neuroactive ligand-receptor interaction
Dopaminergic synapsehsa04015:Rap1 signaling pathway
cAMP signaling pathway
Gap junction
Dopaminergic synapse
Parkinson's disease
Cocaine addiction
Alcoholism
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Dopamine receptor mediated signaling pathway
Nicotine pharmacodynamics pathway
Reactome Dopamine receptors
G alpha (i) signalling eventsR-HSA-390651:Dopamine receptors
G alpha (i) signalling events
WikiPathways Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signaling
Nicotine Activity on Dopaminergic Neurons
GPCRs, OtherWP666:Hypothetical Network for Drug Addiction
Genes and (Common) Pathways Underlying Drug Addiction
References
Ref 532971The dopamine stabilizer (-)-OSU6162 occupies a subpopulation of striatal dopamine D2/D3 receptors: an [(11)C]raclopride PET study in healthy human subjects. Neuropsychopharmacology. 2015 Jan;40(2):472-9.
Ref 532971The dopamine stabilizer (-)-OSU6162 occupies a subpopulation of striatal dopamine D2/D3 receptors: an [(11)C]raclopride PET study in healthy human subjects. Neuropsychopharmacology. 2015 Jan;40(2):472-9.

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