Drug Information

Drug General Information
Drug ID
D0G0OV
Former ID
DNC013469
Drug Name
2-phenylethynyl-5,6,7,8-tetrahydro-quinoline
Drug Type
Small molecular drug
Indication Discovery agent Investigative [529241]
Formula
C17H15N
Canonical SMILES
C1CCC2=C(C1)C=CC(=N2)C#CC3=CC=CC=C3
InChI
1S/C17H15N/c1-2-6-14(7-3-1)10-12-16-13-11-15-8-4-5-9-17(15)18-16/h1-3,6-7,11,13H,4-5,8-9H2
InChIKey
WGJNWKPVRLKAIF-UHFFFAOYSA-N
PubChem Compound ID
24777940
Target and Pathway
Target(s) Metabotropic glutamate receptor 5 Target Info Inhibitor [529241]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Gap junction
Long-term potentiation
Retrograde endocannabinoid signaling
Glutamatergic synapse
Huntington's disease
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Metabotropic glutamate receptor group III pathway
Metabotropic glutamate receptor group I pathway
Endogenous cannabinoid signaling
Reactome G alpha (q) signalling events
Class C/3 (Metabotropic glutamate/pheromone receptors)
WikiPathways Hypothetical Network for Drug Addiction
GPCRs, Class C Metabotropic glutamate, pheromone
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR ligand binding
GPCR downstream signaling
References
Ref 529241J Med Chem. 2008 Feb 14;51(3):634-47. Epub 2008 Jan 4.Positive and negative modulation of group I metabotropic glutamate receptors.
Ref 529241J Med Chem. 2008 Feb 14;51(3):634-47. Epub 2008 Jan 4.Positive and negative modulation of group I metabotropic glutamate receptors.

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