Drug Information

Drug General Information
Drug ID
D0FR4S
Former ID
DNC013056
Drug Name
4-(2-aminoethyl)-1,2,5-oxadiazol-3-ol
Drug Type
Small molecular drug
Indication Discovery agent Investigative [528295]
Formula
C4H7N3O2
Canonical SMILES
C(CN)C1=NONC1=O
InChI
1S/C4H7N3O2/c5-2-1-3-4(8)7-9-6-3/h1-2,5H2,(H,7,8)
InChIKey
LGTWAFYEFVSZIU-UHFFFAOYSA-N
PubChem Compound ID
11607975
Target and Pathway
Target(s) Gamma-aminobutyric acid receptor subunit alpha-1 Target Info Inhibitor [528295]
Gamma-aminobutyric acid receptor Target Info Inhibitor [528295]
Gamma-aminobutyric acid receptor subunit gamma-2 Target Info Inhibitor [528295]
Gamma-aminobutyric acid receptor subunit beta-2 Target Info Inhibitor [528295]
KEGG Pathway Neuroactive ligand-receptor interaction
Retrograde endocannabinoid signaling
GABAergic synapse
Morphine addiction
Nicotine addictionhsa04080:Neuroactive ligand-receptor interaction
Serotonergic synapse
Nicotine addiction
Reactome Ligand-gated ion channel transport
GABA A receptor activationR-HSA-975298:Ligand-gated ion channel transport
GABA A receptor activation
WikiPathways SIDS Susceptibility Pathways
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
Iron uptake and transportWP2754:Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
Iron uptake and transport
References
Ref 528295J Med Chem. 2006 Jul 13;49(14):4442-6.Hydroxy-1,2,5-oxadiazolyl moiety as bioisoster of the carboxy function. Synthesis, ionization constants, and pharmacological characterization of gamma-aminobutyric acid (GABA) related compounds.
Ref 528295J Med Chem. 2006 Jul 13;49(14):4442-6.Hydroxy-1,2,5-oxadiazolyl moiety as bioisoster of the carboxy function. Synthesis, ionization constants, and pharmacological characterization of gamma-aminobutyric acid (GABA) related compounds.

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