Drug Information

Drug General Information
Drug ID
D0FQ4M
Former ID
DIB014549
Drug Name
Selenotifen
Synonyms
BN-52256
Indication Asthma [ICD10:J45] Terminated [544859]
Company
Ipsen
Canonical SMILES
c12C(=C3CCN(CC3)C)c3c(CC(=O)c1[se]cc2)cccc3
CAS Number
CAS 135472-91-2
Target and Pathway
Target(s) Histamine H1 receptor Target Info Modulator [527929]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Inflammatory mediator regulation of TRP channels
PANTHER Pathway Histamine H1 receptor mediated signaling pathway
Reactome Histamine receptors
G alpha (q) signalling events
WikiPathways Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
IL-4 Signaling Pathway
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR ligand binding
GPCR downstream signaling
References
Ref 544859Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800001341)
Ref 527929Effect of BN 52256 and other mediator antagonists on ouabain-induced cardiac arrhythmia in a model of anaphylaxis in guinea-pigs. Pharmacol Res. 1992 Feb-Mar;25(2):173-80.

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