Drug Information

Drug General Information
Drug ID
D0FK3W
Former ID
DNC013377
Drug Name
2-(3-bromophenyl)pyrido[2,3-d]pyrimidine
Drug Type
Small molecular drug
Indication Discovery agent Investigative [528998]
Formula
C13H8BrN3
Canonical SMILES
C1=CC(=CC(=C1)Br)C2=NC=C3C=CC=NC3=N2
InChI
1S/C13H8BrN3/c14-11-5-1-3-9(7-11)12-16-8-10-4-2-6-15-13(10)17-12/h1-8H
InChIKey
KOBJRMNXIZSOES-UHFFFAOYSA-N
PubChem Compound ID
44435039
Target and Pathway
Target(s) Metabotropic glutamate receptor 5 Target Info Inhibitor [528998]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Gap junction
Long-term potentiation
Retrograde endocannabinoid signaling
Glutamatergic synapse
Huntington's disease
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Metabotropic glutamate receptor group III pathway
Metabotropic glutamate receptor group I pathway
Endogenous cannabinoid signaling
Reactome G alpha (q) signalling events
Class C/3 (Metabotropic glutamate/pheromone receptors)
WikiPathways Hypothetical Network for Drug Addiction
GPCRs, Class C Metabotropic glutamate, pheromone
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR ligand binding
GPCR downstream signaling
References
Ref 528998Bioorg Med Chem Lett. 2007 Oct 1;17(19):5396-9. Epub 2007 Aug 6.Synthesis and SAR of 2-aryl pyrido[2,3-d]pyrimidines as potent mGlu5 receptor antagonists.
Ref 528998Bioorg Med Chem Lett. 2007 Oct 1;17(19):5396-9. Epub 2007 Aug 6.Synthesis and SAR of 2-aryl pyrido[2,3-d]pyrimidines as potent mGlu5 receptor antagonists.

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