Drug Information

Drug General Information
Drug ID
D0FE7A
Former ID
DIB020857
Drug Name
RS 67333
Synonyms
RS-67333
Drug Type
Small molecular drug
Indication Discovery agent Investigative [539507]
Formula
C19H29ClN2O2
InChI
InChI=1S/C19H29ClN2O2/c1-3-4-9-22-10-7-14(8-11-22)5-6-18(23)15-12-16(20)17(21)13-19(15)24-2/h12-14H,3-11,21H2,1-2H3
InChIKey
JBHLYIVFFLNISJ-UHFFFAOYSA-N
PubChem Compound ID
183782
PubChem Substance ID
5765198, 10259997, 11113836, 15274331, 26752010, 33506182, 47285925, 47359961, 47510138, 47510139, 57395887, 78960965, 85209764, 85788123, 103286284, 104440468, 126522469, 128250335, 135161335, 135650947, 136351050, 137129339, 162223605, 179236181, 223536019, 226857842
Target and Pathway
Target(s) 5-hydroxytryptamine 4 receptor Target Info Agonist [525888]
KEGG Pathway Calcium signaling pathway
cAMP signaling pathway
Neuroactive ligand-receptor interaction
Serotonergic synapse
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
5HT4 type receptor mediated signaling pathway
PathWhiz Pathway Excitatory Neural Signalling Through 5-HTR 4 and Serotonin
Reactome Serotonin receptors
G alpha (s) signalling events
WikiPathways Serotonin Receptor 4/6/7 and NR3C Signaling
Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signaling
References
Ref 539507(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 237).
Ref 525888Pharmacological characterization of the human 5-HT(4(d)) receptor splice variant stably expressed in Chinese hamster ovary cells. Br J Pharmacol. 2000 Oct;131(4):827-35.

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