Drug Information

Drug General Information
Drug ID
D0FD2I
Former ID
DIB004598
Drug Name
Discodermolide
Synonyms
Discodermolide, Novartis; XAA-296
Drug Type
Small molecular drug
Indication Immuno-suppressant [ICD10:T86.0] Discontinued in Phase 1 [546438]
Company
Harbor Branch Oceanographic Institute Inc
Formula
C33H55NO8
Canonical SMILES
C1(=O)[C@@H]([C@H]([C@H]([C@@H](O1)C[C@@H](/C=C\[C@@H](<br />[C@@H]([C@H](/C=C(\C[C@@H]([C@H]([C@@H]([C@@H](OC(=O)N)<br />[C@H](/C=C\C=C)C)C)O)C)/C)C)O)C)O)C)O)C
CAS Number
CAS 127943-53-7
PubChem Compound ID
643668
Target and Pathway
Target(s) Tubulin Target Info Modulator [534515]
References
Ref 546438Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800008133)
Ref 534515The microtubule-stabilizing agent discodermolide competitively inhibits the binding of paclitaxel (Taxol) to tubulin polymers, enhances tubulin nucleation reactions more potently than paclitaxel, andinhibits the growth of paclitaxel-resistant cells. Mol Pharmacol. 1997 Oct;52(4):613-22.

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