Drug Information

Drug General Information
Drug ID
D0F9BX
Former ID
DIB003264
Drug Name
GW-660511
Synonyms
GW-660511X; Z-13752A
Indication Hypertension [ICD9: 401; ICD10:I10-I16] Terminated [525698]
Company
Zambon Co SpA
Canonical SMILES
C(=O)(N[C@H](C(=O)O)Cc1ccc(c2nccs2)cc1)[C@H](Cc1ccccc1)<br />CS
CAS Number
CAS 193420-09-6
Target and Pathway
Target(s) Neutral endopeptidase Target Info Modulator [525698]
Angiotensin-converting enzyme Target Info Modulator [525698]
KEGG Pathway Renin-angiotensin system
Hematopoietic cell lineage
Protein digestion and absorption
Alzheimer's diseasehsa04614:Renin-angiotensin system
Chagas disease (American trypanosomiasis)
Hypertrophic cardiomyopathy (HCM)
NetPath Pathway EGFR1 Signaling Pathway
TGF_beta_Receptor Signaling Pathway
PathWhiz Pathway Angiotensin Metabolism
Reactome Metabolism of Angiotensinogen to AngiotensinsR-HSA-2022377:Metabolism of Angiotensinogen to Angiotensins
WikiPathways Metabolism of Angiotensinogen to Angiotensins
Primary Focal Segmental Glomerulosclerosis FSGS
Alzheimers DiseaseWP554:ACE Inhibitor Pathway
References
Ref 525698The effects of Z13752A, a combined ACE/NEP inhibitor, on responses to coronary artery occlusion; a primary protective role for bradykinin. Br J Pharmacol. 2000 Feb;129(4):671-80.
Ref 525698The effects of Z13752A, a combined ACE/NEP inhibitor, on responses to coronary artery occlusion; a primary protective role for bradykinin. Br J Pharmacol. 2000 Feb;129(4):671-80.

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