Drug Information

Drug General Information
Drug ID
D0F7KC
Former ID
DNC011340
Drug Name
8-acetyl-7-methoxy-2H-chromen-2-one
Drug Type
Small molecular drug
Indication Discovery agent Investigative [531259]
Formula
C12H10O4
Canonical SMILES
CC(=O)C1=C(C=CC2=C1OC(=O)C=C2)OC
InChI
1S/C12H10O4/c1-7(13)11-9(15-2)5-3-8-4-6-10(14)16-12(8)11/h3-6H,1-2H3
InChIKey
OTYBDEHZHXKGBO-UHFFFAOYSA-N
PubChem Compound ID
14116752
Target and Pathway
Target(s) Carbonic anhydrase IX Target Info Inhibitor [531259]
KEGG Pathway Nitrogen metabolism
Pathway Interaction Database HIF-1-alpha transcription factor network
Reactome Regulation of gene expression by Hypoxia-inducible Factor
Reversible hydration of carbon dioxide
WikiPathways Vitamin D Receptor Pathway
Reversible Hydration of Carbon Dioxide
Regulation of Hypoxia-inducible Factor (HIF) by Oxygen
References
Ref 531259Bioorg Med Chem Lett. 2010 Dec 15;20(24):7255-8. Epub 2010 Oct 25.7,8-disubstituted- but not 6,7-disubstituted coumarins selectively inhibit the transmembrane, tumor-associated carbonic anhydrase isoforms IX and XII over the cytosolic ones I and II in the low nanomolar/subnanomolar range.
Ref 531259Bioorg Med Chem Lett. 2010 Dec 15;20(24):7255-8. Epub 2010 Oct 25.7,8-disubstituted- but not 6,7-disubstituted coumarins selectively inhibit the transmembrane, tumor-associated carbonic anhydrase isoforms IX and XII over the cytosolic ones I and II in the low nanomolar/subnanomolar range.

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