Drug Information

Drug General Information
Drug ID
D0F4TV
Former ID
DIB015160
Drug Name
AWD-12-281
Synonyms
GW-842470; AWD-12-343; AWD-12-281 (COPD), elbion/GlaxoSmithKline; AWD-12-281 (allergic rhinitis), elbion/GlaxoSmithKline; AWD-12-281 (asthma), elbion/GlaxoSmithKline; AWD-12-281 (inhaled), elbion/GlaxoSmithKline; AWD-12-281 (intranasal), elbion/GlaxoSmithKline; 842470
Drug Type
Small molecular drug
Indication Rhinitis [ICD9: 472.0, 477; ICD10:J00, J30, J31.0] Phase 2 [521859]
Company
ASTA Medica AG
Formula
C22H14Cl2FN3O3
Canonical SMILES
c1(cn(c2c1cc(cc2)O)Cc1ccc(F)cc1)C(=O)C(=O)Nc1c(Cl)cncc1<br />Cl
CAS Number
CAS 257892-33-4
PubChem Compound ID
6918428
Target and Pathway
Target(s) CAMP-specific 3',5'-cyclic phosphodiesterase 4B Target Info Inhibitor [527926]
Type IV phosphodiesterase Target Info Inhibitor [527926]
CAMP-specific 3',5'-cyclic phosphodiesterase 4A Target Info Inhibitor [527926]
KEGG Pathway Purine metabolism
cAMP signaling pathway
Morphine addictionhsa00230:Purine metabolism
Morphine addiction
NetPath Pathway IL5 Signaling Pathway
IL2 Signaling Pathway
PathWhiz Pathway Purine Metabolism
Reactome DARPP-32 events
G alpha (s) signalling eventsR-HSA-180024:DARPP-32 events
G alpha (s) signalling events
WikiPathways G Protein Signaling Pathways
Myometrial Relaxation and Contraction Pathways
Nuclear Receptors Meta-Pathway
Opioid SignallingWP35:G Protein Signaling Pathways
TSH signaling pathwayWP35:G Protein Signaling Pathways
References
Ref 521859ClinicalTrials.gov (NCT00354510) Topical GW842470X In Adults Patients With Moderate Atopic Dermatitis. U.S. National Institutes of Health.
Ref 527926The phosphodiesterase 4 inhibitor AWD 12-281 is active in a new guinea-pig model of allergic skin inflammation predictive of human skin penetration and suppresses both Th1 and Th2 cytokines in mice. J Pharm Pharmacol. 2005 Dec;57(12):1609-17.

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