Drug Information

Drug General Information
Drug ID
D0F3FB
Former ID
DIB006072
Drug Name
S-9977
Synonyms
S-9977-2
Drug Type
Small molecular drug
Indication Cognitive disorders [ICD9: 290-294, 294.0, 780.09, 780.9, 780.93; ICD10:F01-F07, F04, F05, R41.3] Discontinued in Phase 2 [544962]
Company
Servier
Formula
C20H34ClN7O3
Canonical SMILES
c12c(c(=O)n(c(=O)n1C)C)n(c(n2)CCCN1CCN(C(=O)N(CC)CC)CC1<br />)C.Cl
CAS Number
CAS 138472-18-1
PubChem Compound ID
132156
Target and Pathway
Target(s) Acetylcholinesterase Target Info Inhibitor [526803]
KEGG Pathway Glycerophospholipid metabolism
Cholinergic synapse
PANTHER Pathway Muscarinic acetylcholine receptor 1 and 3 signaling pathway
Muscarinic acetylcholine receptor 2 and 4 signaling pathway
Nicotinic acetylcholine receptor signaling pathway
Pathway Interaction Database ATF-2 transcription factor network
PathWhiz Pathway Phospholipid Biosynthesis
WikiPathways Monoamine Transport
Biogenic Amine Synthesis
Acetylcholine Synthesis
Integrated Pancreatic Cancer Pathway
References
Ref 544962Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800001724)
Ref 526803Xanthine derivatives IBMX and S-9977-2 potentiate transmission at an Aplysia central cholinergic synapse. Brain Res. 1992 Jul 17;586(1):78-85.

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