Drug Information

Drug General Information
Drug ID
D0F3CA
Former ID
DNC007255
Drug Name
3,4-dichloroisocoumarin
Drug Type
Small molecular drug
Indication Discovery agent Investigative [528555]
Formula
C9H4Cl2O2
Canonical SMILES
C1=CC=C2C(=C1)C(=C(OC2=O)Cl)Cl
InChI
1S/C9H4Cl2O2/c10-7-5-3-1-2-4-6(5)9(12)13-8(7)11/h1-4H
InChIKey
SUGXUUGGLDCZKB-UHFFFAOYSA-N
PubChem Compound ID
1609
Target and Pathway
Target(s) Leukocyte elastase Target Info Inhibitor [528555]
KEGG Pathway Transcriptional misregulation in cancer
Systemic lupus erythematosus
Pathway Interaction Database Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
C-MYB transcription factor network
Reactome Collagen degradation
Degradation of the extracellular matrix
Activation of Matrix Metalloproteinases
WikiPathways Hair Follicle Development: Cytodifferentiation (Part 3 of 3)
Human Complement System
Degradation of collagen
References
Ref 528555Antimicrob Agents Chemother. 2007 Feb;51(2):543-50. Epub 2006 Dec 4.Cathepsin A is the major hydrolase catalyzing the intracellular hydrolysis of the antiretroviral nucleotide phosphonoamidate prodrugs GS-7340 and GS-9131.
Ref 528555Antimicrob Agents Chemother. 2007 Feb;51(2):543-50. Epub 2006 Dec 4.Cathepsin A is the major hydrolase catalyzing the intracellular hydrolysis of the antiretroviral nucleotide phosphonoamidate prodrugs GS-7340 and GS-9131.

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