Drug Information

Drug General Information
Drug ID
D0EY1K
Former ID
DIB011608
Drug Name
CB1 antagonists
Synonyms
CB1 antagonists (endocrine/neurological diseases); CB1 antagonists (endocrine disease), Schering-Plough; CB1 antagonists (neurological disease), Schering-Plough; CB1 antagonists (endocrine/neurological diseases), Merck & Co
Indication Endocrine disease [ICD10:E00-E35] Investigative [552035]
Company
Schering-Plough Corp
Canonical SMILES
[C@@H]1([C@@H](CC[C@@]2(C1[C@H](NC2=O)C)CC)c1cc(cc(c1)C<br />l)OCCO)c1ccc(cc1)Cl
Target and Pathway
Target(s) Cannabinoid receptor 1 Target Info Antagonist [543877]
KEGG Pathway Rap1 signaling pathway
Neuroactive ligand-receptor interaction
Retrograde endocannabinoid signaling
PANTHER Pathway Endogenous cannabinoid signaling
Pathway Interaction Database N-cadherin signaling events
Reactome Class A/1 (Rhodopsin-like receptors)
G alpha (i) signalling events
WikiPathways GPCRs, Class A Rhodopsin-like
Small Ligand GPCRs
BDNF signaling pathway
GPCR ligand binding
GPCR downstream signaling
GPCRs, Other
References
Ref 552035Identification of novel cannabinoid CB1 receptor antagonists by using virtual screening with a pharmacophore model. J Med Chem. 2008 Apr 24;51(8):2439-46
Ref 543877(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 56).

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