Drug Information

Drug General Information
Drug ID
D0ER0L
Former ID
DNC012886
Drug Name
4-Benzyl-5-piperidin-4-yl-isoxazol-3-ol
Drug Type
Small molecular drug
Indication Discovery agent Investigative [527382]
Formula
C15H18N2O2
Canonical SMILES
C1CNCCC1C2=C(C(=O)NO2)CC3=CC=CC=C3
InChI
1S/C15H18N2O2/c18-15-13(10-11-4-2-1-3-5-11)14(19-17-15)12-6-8-16-9-7-12/h1-5,12,16H,6-10H2,(H,17,18)
InChIKey
UQASDRGKIOGECB-UHFFFAOYSA-N
PubChem Compound ID
10491441
Target and Pathway
Target(s) Gamma-aminobutyric acid receptor subunit alpha-1 Target Info Inhibitor [527382]
Gamma-aminobutyric acid receptor subunit beta-2 Target Info Inhibitor [527382]
Gamma-aminobutyric acid receptor Target Info Inhibitor [527382]
Gamma-aminobutyric acid receptor subunit gamma-2 Target Info Inhibitor [527382]
KEGG Pathway Neuroactive ligand-receptor interaction
Retrograde endocannabinoid signaling
GABAergic synapse
Morphine addiction
Nicotine addictionhsa04080:Neuroactive ligand-receptor interaction
Serotonergic synapse
Nicotine addiction
Reactome Ligand-gated ion channel transport
GABA A receptor activationR-HSA-975298:Ligand-gated ion channel transport
GABA A receptor activation
WikiPathways SIDS Susceptibility Pathways
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
Iron uptake and transportWP2754:Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
Iron uptake and transport
References
Ref 527382J Med Chem. 2005 Jan 27;48(2):427-39.Potent 4-aryl- or 4-arylalkyl-substituted 3-isoxazolol GABA(A) antagonists: synthesis, pharmacology, and molecular modeling.
Ref 527382J Med Chem. 2005 Jan 27;48(2):427-39.Potent 4-aryl- or 4-arylalkyl-substituted 3-isoxazolol GABA(A) antagonists: synthesis, pharmacology, and molecular modeling.

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