Drug Information

Drug General Information
Drug ID
D0E9BF
Former ID
DIB011740
Drug Name
5-hydroxymethyl-2-furfural (sickle cell disease), AesRx LLC
Synonyms
Aes-103; 5-HMF; 5-hydroxymethylfurfural
Indication Anemia [ICD9: 280-285; ICD10:D50-D64] Phase 2 [524529]
Company
Aesrx
Canonical SMILES
o1c(ccc1CO)C=O
Target and Pathway
Target(s) Hemoglobin Target Info Modulator [527406]
KEGG Pathway African trypanosomiasis
Malaria
Reactome Erythrocytes take up carbon dioxide and release oxygen
Erythrocytes take up oxygen and release carbon dioxide
Scavenging of heme from plasma
WikiPathways Binding and Uptake of Ligands by Scavenger Receptors
Uptake of Carbon Dioxide and Release of Oxygen by Erythrocytes
Uptake of Oxygen and Release of Carbon Dioxide by Erythrocytes
Factors involved in megakaryocyte development and platelet production
Folate Metabolism
Vitamin B12 Metabolism
Selenium Micronutrient Network
References
Ref 524529ClinicalTrials.gov (NCT01987908) Evaluation of Different Dose Regimens of Aes-103 Given for 28 Days to Subjects With Stable Sickle Cell Disease. U.S. National Institutes of Health.
Ref 5274065-hydroxymethyl-2-furfural modifies intracellular sickle haemoglobin and inhibits sickling of red blood cells. Br J Haematol. 2005 Feb;128(4):552-61.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Tang and Dr. Zhang.