Drug Information

Drug General Information
Drug ID
D0E3ID
Former ID
DNC004299
Drug Name
7-Iodo-1,5-dihydro-imidazo[2,1-b]quinazolin-2-one
Drug Type
Small molecular drug
Indication Discovery agent Investigative [533367]
Formula
C10H8IN3O
Canonical SMILES
C1C2=C(C=CC(=C2)I)NC3=NC(=O)CN31
InChI
1S/C10H8IN3O/c11-7-1-2-8-6(3-7)4-14-5-9(15)13-10(14)12-8/h1-3H,4-5H2,(H,12,13,15)
InChIKey
JJEAICNWSUWOMH-UHFFFAOYSA-N
PubChem Compound ID
14177141
Target and Pathway
Target(s) CGMP-inhibited 3',5'-cyclic phosphodiesterase A Target Info Inhibitor [533367]
KEGG Pathway Purine metabolism
cGMP-PKG signaling pathway
cAMP signaling pathway
Morphine addiction
Reactome cGMP effects
G alpha (s) signalling events
WikiPathways miR-targeted genes in muscle cell - TarBase
miR-targeted genes in lymphocytes - TarBase
References
Ref 533367J Med Chem. 1988 Nov;31(11):2136-45.Inhibitors of cyclic AMP phosphodiesterase. 3. Synthesis and biological evaluation of pyrido and imidazolyl analogues of 1,2,3,5-tetrahydro-2-oxoimidazo[2,1-b]quinazoline.
Ref 533367J Med Chem. 1988 Nov;31(11):2136-45.Inhibitors of cyclic AMP phosphodiesterase. 3. Synthesis and biological evaluation of pyrido and imidazolyl analogues of 1,2,3,5-tetrahydro-2-oxoimidazo[2,1-b]quinazoline.

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