Drug Information

Drug General Information
Drug ID
D0E0WL
Former ID
DIB005023
Drug Name
CCR5 receptor inhibitors
Synonyms
CCR5 receptor inhibitors (HIV infection); CCR5 antagonists (HIV infection), Kemia; CCR5 receptor (HIV infection), Kemia; CCR5 receptor inhibitors (HIV infection), Kemia
Indication Human immunodeficiency virus infection [ICD9: 279.3; ICD10:B20-B26] Terminated [548211]
Company
Kemia Inc
Target and Pathway
Target(s) C-C chemokinereceptor type 5 Target Info Antagonist [529636]
KEGG Pathway Cytokine-cytokine receptor interaction
Chemokine signaling pathway
Endocytosis
Toxoplasmosis
Viral carcinogenesis
NetPath Pathway TSLP Signaling Pathway
TCR Signaling Pathway
IL2 Signaling Pathway
PANTHER Pathway Inflammation mediated by chemokine and cytokine signaling pathway
Pathway Interaction Database IL12-mediated signaling events
Reactome Binding and entry of HIV virion
Chemokine receptors bind chemokines
G alpha (i) signalling events
WikiPathways TCR Signaling Pathway
GPCRs, Class A Rhodopsin-like
HIV Life Cycle
Peptide GPCRs
GPCR ligand binding
GPCR downstream signaling
GPCRs, Other
References
Ref 548211Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800023138)
Ref 529636Maraviroc: a CCR5-receptor antagonist for the treatment of HIV-1 infection. Clin Ther. 2008 Jul;30(7):1228-50.

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