Drug Information

Drug General Information
Drug ID
D0DW8G
Former ID
DIB000457
Drug Name
Estrogen receptor beta-selective phytoestrogenic formulation
Synonyms
Phyto-beta-SERM; Estrogen receptor beta-selective phytoestrogenic formulation (Alzheimer's disease/menopause); ERbeta-SERM (Alzheimer's disease/menopause), USC; Estrogen receptor beta-selective phytoestrogenic formulation (Alzheimer's disease/menopause), University of Southern California
Indication Menopause symptoms [ICD10:N95.0] Phase 2 [531544]
Company
University of Southern California
Target and Pathway
Target(s) Estrogen receptor Target Info Modulator [527132]
KEGG Pathway Estrogen signaling pathway
Prolactin signaling pathway
Thyroid hormone signaling pathway
Endocrine and other factor-regulated calcium reabsorption
Proteoglycans in cancer
NetPath Pathway FSH Signaling Pathway
EGFR1 Signaling Pathway
RANKL Signaling Pathway
Pathway Interaction Database Regulation of nuclear SMAD2/3 signaling
Signaling events mediated by HDAC Class II
Plasma membrane estrogen receptor signaling
LKB1 signaling events
Regulation of Telomerase
ATF-2 transcription factor network
AP-1 transcription factor network
FOXM1 transcription factor network
Validated nuclear estrogen receptor alpha network
Signaling mediated by p38-alpha and p38-beta
FOXA1 transcription factor network
Reactome Nuclear signaling by ERBB4
Nuclear Receptor transcription pathway
WikiPathways Estrogen signaling pathway
Nuclear Receptors Meta-Pathway
Estrogen Receptor Pathway
Signaling by ERBB4
JAK/STAT
Integrated Pancreatic Cancer Pathway
Leptin signaling pathway
miR-targeted genes in muscle cell - TarBase
Integrated Breast Cancer Pathway
Nuclear Receptors
References
Ref 531544Estrogen receptor beta-selective phytoestrogenic formulation prevents physical and neurological changes in a preclinical model of human menopause. Menopause. 2011 Oct;18(10):1131-42.
Ref 527132A structural explanation for ERalpha/ERbeta SERM discrimination. Ernst Schering Res Found Workshop. 2004;(46):33-45.

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