Drug Information

Drug General Information
Drug ID
D0D9PH
Former ID
DIB008083
Drug Name
Small molecule 18a
Synonyms
Pim-1 kinase inhibitors (cancer); Pim-1 kinase inhibitors (cancer), Vertex
Indication Cancer [ICD9: 140-229; ICD10:C00-C96] Investigative [543563]
Company
Vertex Pharmaceuticals Inc
Canonical SMILES
c1c(nn2c(c1)nnc2c1cccc(c1)C(F)(F)F)N[C@H]1CC[C@@H](CC1)<br />O
Target and Pathway
Target(s) Proto-oncogene pim-1 Target Info Inhibitor [543563]
KEGG Pathway Jak-STAT signaling pathway
MicroRNAs in cancer
Acute myeloid leukemia
NetPath Pathway IL9 Signaling Pathway
IL5 Signaling Pathway
IL2 Signaling Pathway
TGF_beta_Receptor Signaling Pathway
TCR Signaling Pathway
Pathway Interaction Database GMCSF-mediated signaling events
Validated targets of C-MYC transcriptional activation
Role of Calcineurin-dependent NFAT signaling in lymphocytes
IL5-mediated signaling events
IL3-mediated signaling events
C-MYB transcription factor network
WikiPathways Ectoderm Differentiation
Hematopoietic Stem Cell Differentiation
References
Ref 543563(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2158).
Ref 543563(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2158).

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