Drug Information

Drug General Information
Drug ID
D0D8YE
Former ID
DNC006351
Drug Name
3-(5-methoxy-1H-inden-2-yl)pyridine
Drug Type
Small molecular drug
Indication Discovery agent Investigative [528109]
Formula
C15H13NO
Canonical SMILES
COC1=CC2=C(CC(=C2)C3=CN=CC=C3)C=C1
InChI
1S/C15H13NO/c1-17-15-5-4-11-7-13(8-14(11)9-15)12-3-2-6-16-10-12/h2-6,8-10H,7H2,1H3
InChIKey
KPJYOCDWGFDTFR-UHFFFAOYSA-N
PubChem Compound ID
6540048
Target and Pathway
Target(s) Cytochrome P450 11B1, mitochondrial Target Info Inhibitor [528109]
BioCyc Pathway Superpathway of steroid hormone biosynthesis
Glucocorticoid biosynthesis
Mineralocorticoid biosynthesis
KEGG Pathway Steroid hormone biosynthesis
Metabolic pathways
PathWhiz Pathway Steroidogenesis
Reactome Glucocorticoid biosynthesis
Endogenous sterols
WikiPathways Metapathway biotransformation
Oxidation by Cytochrome P450
Metabolism of steroid hormones and vitamin D
Corticotropin-releasing hormone
References
Ref 528109J Med Chem. 2006 Apr 6;49(7):2222-31.Synthesis and evaluation of heteroaryl-substituted dihydronaphthalenes and indenes: potent and selective inhibitors of aldosterone synthase (CYP11B2) for the treatment of congestive heart failure and myocardial fibrosis.
Ref 528109J Med Chem. 2006 Apr 6;49(7):2222-31.Synthesis and evaluation of heteroaryl-substituted dihydronaphthalenes and indenes: potent and selective inhibitors of aldosterone synthase (CYP11B2) for the treatment of congestive heart failure and myocardial fibrosis.

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