Drug Information

Drug General Information
Drug ID
D0D8TE
Former ID
DIB014537
Drug Name
FBS-0701
Synonyms
Desferrithiocin analog (oral, iron overload), FerroKin Biosciences; Iron chelator (oral, iron overload), FerroKin Biosciences
Drug Type
Small molecular drug
Indication Iron overload [ICD10:R79.0] Phase 2 [523142]
Company
FerroKin BioSciences Inc
Formula
C18H25NO7S
Canonical SMILES
N1=C(c2cccc(c2O)OCCOCCOCCOC)SC[C@@]1(C(=O)O)C.[Mg](O)O
PubChem Compound ID
71587885
Target and Pathway
Target(s) Hemoglobin Target Info Modulator [525388]
KEGG Pathway African trypanosomiasis
Malaria
Reactome Erythrocytes take up carbon dioxide and release oxygen
Erythrocytes take up oxygen and release carbon dioxide
Scavenging of heme from plasma
WikiPathways Binding and Uptake of Ligands by Scavenger Receptors
Uptake of Carbon Dioxide and Release of Oxygen by Erythrocytes
Uptake of Oxygen and Release of Carbon Dioxide by Erythrocytes
Factors involved in megakaryocyte development and platelet production
Folate Metabolism
Vitamin B12 Metabolism
Selenium Micronutrient Network
References
Ref 523142ClinicalTrials.gov (NCT01186419) Safety and Pharmacodynamic Study of an Oral Iron Chelator Given for 6 Months to Patients With Iron Overload. U.S. National Institutes of Health.
Ref 525388A high-affinity fully human anti-IL-6 mAb, 1339, for the treatment of multiple myeloma. Clin Cancer Res. 2009 Dec 1;15(23):7144-52.

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