Drug Information

Drug General Information
Drug ID
D0D7XW
Former ID
DIB000927
Drug Name
SINITRODIL
Synonyms
ITF-296; Sinitrodil < Prop INN >; 3-[2-(Nitrooxy)ethyl]-2H-1,3-benzoxazin-4(3H)-one
Drug Type
Small molecular drug
Indication Angina pectoris [ICD9: 413; ICD10:I20] Discontinued in Phase 2 [545952]
Formula
C10H10N2O5
Canonical SMILES
[O-][N+](=O)OCCN1COc2ccccc2C1=O
InChI
1S/C10H10N2O5/c13-10-8-3-1-2-4-9(8)16-7-11(10)5-6-17-12(14)15/h1-4H,5-7H2
InChIKey
POVFCWQCRHXYAB-UHFFFAOYSA-N
CAS Number
CAS 143248-63-9
PubChem Compound ID
121985
Target and Pathway
Target(s) CGMP-specific 3',5'-cyclic phosphodiesterase Target Info Modulator [551871]
KEGG Pathway Purine metabolism
cGMP-PKG signaling pathway
NetPath Pathway TGF_beta_Receptor Signaling Pathway
Reactome cGMP effects
References
Ref 545952Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800005482)
Ref 551871Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015

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