Drug Information

Drug General Information
Drug ID
D0D7UD
Former ID
DIB002523
Drug Name
AS-013
Synonyms
Circulase; Ecraprost; Prostaglandin E1 (liposomal), Mitsubishi Pharma/Asahi Glass
Drug Type
Small molecular drug
Indication Thrombosis [ICD9: 437.6, 453, 671.5, 671.9; ICD10:I80-I82] Phase 3 [534768]
Company
Taisho Pharmaceutical Co Ltd
Formula
C28H48O6
Canonical SMILES
C1(=C([C@@H](/C=C/[C@@H](O)CCCCC)[C@@H](C1)O)CCCCCCC(=O<br />)OCCCC)OC(=O)CCC
CAS Number
CAS 136892-64-3
PubChem Compound ID
6917049
Target and Pathway
Target(s) Prostaglandin E2 receptor, EP1 subtype Target Info Agonist [534768]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Pathways in cancer
PANTHER Pathway PI3 kinase pathway
Reactome Prostanoid ligand receptors
G alpha (q) signalling events
WikiPathways Prostaglandin Synthesis and Regulation
GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
Small Ligand GPCRs
GPCR ligand binding
GPCR downstream signaling
References
Ref 534768Effect of lipo-pro-prostaglandin E1, AS-013 on rat inner ear microcirculatory thrombosis. Prostaglandins Leukot Essent Fatty Acids. 1998 Sep;59(3):203-7.
Ref 534768Effect of lipo-pro-prostaglandin E1, AS-013 on rat inner ear microcirculatory thrombosis. Prostaglandins Leukot Essent Fatty Acids. 1998 Sep;59(3):203-7.

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