Drug Information

Drug General Information
Drug ID
D0D1BC
Former ID
DNC000922
Drug Name
Melanocortin-4 Receptor antagonist
Drug Type
Small molecular drug
Indication Anorexia nervosa cachexia [ICD9: 307.1, 799.4; ICD10:F50.0-F50.1] Investigative [552046]
Company
Santhera
Formula
C17H34O3
Canonical SMILES
COC(=O)CCCCCCCCCCCCCCCO
InChI
1S/C17H34O3/c1-20-17(19)15-13-11-9-7-5-3-2-4-6-8-10-12-14-16-18/h18H,2-16H2,1H3
InChIKey
AOTMRIXFFOGWDT-UHFFFAOYSA-N
PubChem Compound ID
3496888
PubChem Substance ID
4703469, 9727366, 16024205, 37315858, 75209162, 109614001, 112274827, 127437530, 162247445, 162510120, 224606343, 227474671, 249916014
Target and Pathway
Target(s) Melanocortin-4 receptor Target Info Antagonist [536225]
KEGG Pathway Neuroactive ligand-receptor interaction
Pathway Interaction Database Syndecan-3-mediated signaling events
Reactome Peptide ligand-binding receptors
G alpha (s) signalling events
WikiPathways GPCRs, Class A Rhodopsin-like
Peptide GPCRs
GPCR ligand binding
GPCR downstream signaling
References
Ref 552046Orally available selective melanocortin-4 receptor antagonists stimulate food intake and reduce cancer-induced cachexia in mice. PLoS One. 2009;4(3):e4774
Ref 536225Emerging drugs for eating disorder treatment. Expert Opin Emerg Drugs. 2006 May;11(2):315-36.

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