Drug Information

Drug General Information
Drug ID
D0CT7P
Former ID
DNC006453
Drug Name
2-(pyridin-2-yl)-4-(m-tolylthio)pyrimidine
Drug Type
Small molecular drug
Indication Discovery agent Investigative [528038]
Formula
C16H13N3S
Canonical SMILES
CC1=CC(=CC=C1)SC2=NC(=NC=C2)C3=CC=CC=N3
InChI
1S/C16H13N3S/c1-12-5-4-6-13(11-12)20-15-8-10-18-16(19-15)14-7-2-3-9-17-14/h2-11H,1H3
InChIKey
LUFGLBRBPWCPQS-UHFFFAOYSA-N
PubChem Compound ID
11460152
Target and Pathway
Target(s) Metabotropic glutamate receptor 5 Target Info Inhibitor [528038]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Gap junction
Long-term potentiation
Retrograde endocannabinoid signaling
Glutamatergic synapse
Huntington's disease
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Metabotropic glutamate receptor group III pathway
Metabotropic glutamate receptor group I pathway
Endogenous cannabinoid signaling
Reactome G alpha (q) signalling events
Class C/3 (Metabotropic glutamate/pheromone receptors)
WikiPathways Hypothetical Network for Drug Addiction
GPCRs, Class C Metabotropic glutamate, pheromone
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR ligand binding
GPCR downstream signaling
References
Ref 528038Bioorg Med Chem Lett. 2006 May 1;16(9):2467-9. Epub 2006 Feb 14.Structure-activity relationship of thiopyrimidines as mGluR5 antagonists.
Ref 528038Bioorg Med Chem Lett. 2006 May 1;16(9):2467-9. Epub 2006 Feb 14.Structure-activity relationship of thiopyrimidines as mGluR5 antagonists.

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