Drug Information

Drug General Information
Drug ID
D0CR6M
Former ID
DNC012993
Drug Name
6-bromo-3-ethoxycarbonyl-2-methyl-4-quinolone
Drug Type
Small molecular drug
Indication Discovery agent Investigative [528134]
Formula
C13H12BrNO3
Canonical SMILES
CCOC(=O)C1=C(NC2=C(C1=O)C=C(C=C2)Br)C
InChI
1S/C13H12BrNO3/c1-3-18-13(17)11-7(2)15-10-5-4-8(14)6-9(10)12(11)16/h4-6H,3H2,1-2H3,(H,15,16)
InChIKey
OWQFPNVJMALXNK-UHFFFAOYSA-N
PubChem Compound ID
11616547
Target and Pathway
Target(s) Gamma-aminobutyric acid receptor Target Info Inhibitor [528134]
Gamma-aminobutyric acid receptor subunit gamma-2 Target Info Inhibitor [528134]
Gamma-aminobutyric acid receptor subunit beta-2 Target Info Inhibitor [528134]
Gamma-aminobutyric acid receptor subunit alpha-1 Target Info Inhibitor [528134]
KEGG Pathway Neuroactive ligand-receptor interaction
Retrograde endocannabinoid signaling
GABAergic synapse
Morphine addiction
Nicotine addictionhsa04080:Neuroactive ligand-receptor interaction
Serotonergic synapse
Nicotine addiction
Reactome Ligand-gated ion channel transport
GABA A receptor activationR-HSA-975298:Ligand-gated ion channel transport
GABA A receptor activation
WikiPathways Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
Iron uptake and transportWP2754:Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
Iron uptake and transportWP706:SIDS Susceptibility Pathways
Iron uptake and transport
References
Ref 528134J Med Chem. 2006 Apr 20;49(8):2526-33.4-quinolone derivatives: high-affinity ligands at the benzodiazepine site of brain GABA A receptors. synthesis, pharmacology, and pharmacophore modeling.
Ref 528134J Med Chem. 2006 Apr 20;49(8):2526-33.4-quinolone derivatives: high-affinity ligands at the benzodiazepine site of brain GABA A receptors. synthesis, pharmacology, and pharmacophore modeling.

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