Drug Information

Drug General Information
Drug ID
D0CO9Z
Former ID
DIB001092
Drug Name
Edg5 antagonists
Synonyms
Edg5 antagonists, Merck; Sphingosine 1-phosphate 2 antagonist (hypertension), Merck
Indication Hypertension [ICD9: 401; ICD10:I10-I16] Investigative [552105]
Company
Merck & Co Inc
Canonical SMILES
C1N2C(N(C1)C(=O)c1ccccc1Oc1ccccc1)C(=O)N(CC2=O)Cc1c2c(c<br />cc1)cccc2
Target and Pathway
Target(s) Sphingosine-1-phosphate receptor-2 Target Info Antagonist [543702]
KEGG Pathway Sphingolipid signaling pathway
Neuroactive ligand-receptor interaction
Pathway Interaction Database S1P3 pathway
Sphingosine 1-phosphate (S1P) pathway
S1P2 pathway
Reactome G alpha (i) signalling events
Lysosphingolipid and LPA receptors
WikiPathways Signal Transduction of S1P Receptor
Small Ligand GPCRs
GPCR ligand binding
GPCR downstream signaling
References
Ref 552105Sphingosine kinase 1 and sphingosine 1-phosphate receptor 3 are functionally upregulated on astrocytes under pro-inflammatory conditions. PLoS One. 2011;6(8):e23905
Ref 543702(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 276).

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Tang and Dr. Zhang.