Drug Information

Drug General Information
Drug ID
D0C9DC
Former ID
DNC004983
Drug Name
SK&F-64139
Synonyms
SK-64139
Drug Type
Small molecular drug
Indication Discovery agent Investigative [528403]
Formula
C9H9Cl2N
Canonical SMILES
C1CNCC2=C1C=CC(=C2Cl)Cl.Cl
InChI
1S/C9H9Cl2N.ClH/c10-8-2-1-6-3-4-12-5-7(6)9(8)11;/h1-2,12H,3-5H2;1H
InChIKey
MPGYNUDLCXDURR-UHFFFAOYSA-N
PubChem Compound ID
123920
Target and Pathway
Target(s) Alpha-2B adrenergic receptor Target Info Inhibitor [528403]
Alpha-2C adrenergic receptor Target Info Inhibitor [528403]
Alpha-2A adrenergic receptor Target Info Inhibitor [528403]
KEGG Pathway cGMP-PKG signaling pathway
Neuroactive ligand-receptor interactionhsa04022:cGMP-PKG signaling pathway
Neuroactive ligand-receptor interaction
PANTHER Pathway Alpha adrenergic receptor signaling pathway
Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathwayP00002:Alpha adrenergic receptor signaling pathway
Reactome Adrenoceptors
Adrenaline signalling through Alpha-2 adrenergic receptor
G alpha (i) signalling events
G alpha (z) signalling eventsR-HSA-390696:Adrenoceptors
Adrenaline,noradrenaline inhibits insulin secretion
G alpha (z) signalling events
Surfactant metabolismR-HSA-390696:Adrenoceptors
Surfactant metabolism
WikiPathways Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
Platelet Aggregation (Plug Formation)
GPCR ligand binding
GPCR downstream signalingWP58:Monoamine GPCRs
Integration of energy metabolism
GPCR downstream signaling
References
Ref 528403J Med Chem. 2006 Sep 7;49(18):5424-33.Comparison of the binding of 3-fluoromethyl-7-sulfonyl-1,2,3,4-tetrahydroisoquinolines with their isosteric sulfonamides to the active site of phenylethanolamineN-methyltransferase.
Ref 528403J Med Chem. 2006 Sep 7;49(18):5424-33.Comparison of the binding of 3-fluoromethyl-7-sulfonyl-1,2,3,4-tetrahydroisoquinolines with their isosteric sulfonamides to the active site of phenylethanolamineN-methyltransferase.

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