Drug Information

Drug General Information
Drug ID
D0C7LF
Former ID
DIB003694
Drug Name
DACOPAFANT
Synonyms
RP-55778; Dacopafant < Rec INN >; (+)-3(R)-(3-Pyridyl)-1H,3H-pyrrolo[1,2-c]thiazole-7-carboxamide
Drug Type
Small molecular drug
Indication Septic shock [ICD9: 785.52; ICD10:A41.9] Discontinued in Phase 1 [544523]
Formula
C12H11N3OS
Canonical SMILES
NC(=O)c1ccn2C(SCc12)c3cccnc3
InChI
1S/C12H11N3OS/c13-11(16)9-3-5-15-10(9)7-17-12(15)8-2-1-4-14-6-8/h1-6,12H,7H2,(H2,13,16)
InChIKey
ARFOASMERCHFBY-UHFFFAOYSA-N
CAS Number
CAS 125372-33-0
PubChem Compound ID
205955
Target and Pathway
Target(s) Platelet-activating factor receptor Target Info Antagonist [531635], [532945]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Staphylococcus aureus infection
NetPath Pathway IL5 Signaling Pathway
Leptin Signaling Pathway
Reactome Class A/1 (Rhodopsin-like receptors)
G alpha (q) signalling events
Interferon gamma signaling
WikiPathways GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
Small Ligand GPCRs
Interferon gamma signaling
GPCR ligand binding
GPCR downstream signaling
References
Ref 544523Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800000051)
Ref 531635Therapeutic target database update 2012: a resource for facilitating target-oriented drug discovery. Nucleic Acids Res. 2012 Jan;40(Database issue):D1128-36.
Ref 532945RP 55778, a PAF receptor antagonist, prevents and reverses LPS-induced hemoconcentration and TNF release. J Lipid Mediat. 1989 Nov-Dec;1(6):349-60.

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