Drug Information

Drug General Information
Drug ID
D0C6QQ
Former ID
DIB016758
Drug Name
Besipirdine
Synonyms
Besipirdine hydrochloride; HP-749; P-7480; P86-7480
Drug Type
Small molecular drug
Indication Cognitive disorders [ICD9: 290-294, 294.0, 780.09, 780.9, 780.93; ICD10:F01-F07, F04, F05, R41.3] Phase 3 [550094]
Company
Hoechst Marion Roussel Inc
Formula
C16H17N3
Canonical SMILES
n1(ccc2c1cccc2)N(c1ccncc1)CCC
PubChem Compound ID
60691
Target and Pathway
Target(s) Alpha-1A adrenergic receptor Target Info Antagonist [534361]
KEGG Pathway Calcium signaling pathway
cGMP-PKG signaling pathway
Neuroactive ligand-receptor interaction
AMPK signaling pathway
Adrenergic signaling in cardiomyocytes
Vascular smooth muscle contraction
Salivary secretion
PANTHER Pathway Alpha adrenergic receptor signaling pathway
Reactome Adrenoceptors
G alpha (q) signalling events
G alpha (12/13) signalling events
WikiPathways Monoamine GPCRs
Calcium Regulation in the Cardiac Cell
GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
Endothelin Pathways
GPCR ligand binding
GPCR downstream signaling
AMPK Signaling
References
Ref 550094Clinical pipeline report, company report or official report of UroGene.
Ref 534361Alpha-Adrenergic activity and cardiovascular effects of besipirdine HCl (HP 749) and metabolite P7480 in vitro and in the conscious rat and dog. J Pharmacol Exp Ther. 1997 Apr;281(1):337-46.

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