Drug Information

Drug General Information
Drug ID
D0C5NP
Former ID
DND000036
Drug Name
AGG-523
Synonyms
PF-5212371, WAY-266523
Indication Osteoarthritis [ICD9: 715; ICD10:M15-M19, M47] Phase 1 [521997]
Company
Pfizer
Target and Pathway
Target(s) Aggrecanase Target Info Inhibitor [531304]
Reactome Degradation of the extracellular matrix
O-glycosylation of TSR domain-containing proteins
WikiPathways Endochondral Ossification
Vitamin D Receptor Pathway
References
Ref 521997ClinicalTrials.gov (NCT00454298) Study Evaluating AGG-523 in Subjects With Severe Osteoarthritis Requiring Total Knee Replacement. U.S. National Institutes of Health.
Ref 531304Elevated aggrecanase activity in a rat model of joint injury is attenuated by an aggrecanase specific inhibitor. Osteoarthritis Cartilage. 2011 Mar;19(3):315-23.

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