Drug Information

Drug General Information
Drug ID
D0C1ZQ
Former ID
DIB015568
Drug Name
Estrogen receptor beta modulators
Synonyms
IDDBCP245397
Indication Inflammatory disease [ICD9: 140-229, 147, 173, 573.3, 710-719; ICD10:C11, C44, K75.9, M00-M25] Investigative [552016]
Company
GlaxoSmithKline plc
Canonical SMILES
O=S(=O)(N1C2(CCCCC2)C=C(c2ccccc12)C)c1ccc(cc1)O
Target and Pathway
Target(s) Estrogen receptor beta Target Info Modulator [543899]
KEGG Pathway Estrogen signaling pathway
Prolactin signaling pathway
Pathway Interaction Database Plasma membrane estrogen receptor signaling
Validated nuclear estrogen receptor beta network
Validated nuclear estrogen receptor alpha network
Reactome Nuclear Receptor transcription pathway
WikiPathways SIDS Susceptibility Pathways
Ovarian Infertility Genes
Integrated Pancreatic Cancer Pathway
Nuclear Receptors
References
Ref 552016A new series of estrogen receptor modulators that display selectivity for estrogen receptor beta. J Med Chem. 2002 Dec 5;45(25):5492-505.
Ref 543899(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 621).

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