Drug Information

Drug General Information
Drug ID
D0B8SC
Former ID
DIB001878
Drug Name
BOF-4272
Synonyms
Rac-8-[3-Methoxy-4-(phenylsulfinyl)phenyl]pyrazolo[1,5-a]-1,3,5-triazin-4-ol sodium salt hydrate
Drug Type
Small molecular drug
Indication Gout [ICD9: 274.00274.1274.8274.9; ICD10:M10] Discontinued in Phase 2 [545270]
Formula
C18H14N4O3S
Canonical SMILES
COC1=C(C=CC(=C1)C2=CNN3C2=NC=NC3=O)S(=O)C4=CC=CC=C4
InChI
1S/C18H14N4O3S/c1-25-15-9-12(14-10-21-22-17(14)19-11-20-18(22)23)7-8-16(15)26(24)13-5-3-2-4-6-13/h2-11,21H,1H3
InChIKey
RAUZDCRFPSDXRB-UHFFFAOYSA-N
CAS Number
CAS 117411-27-5
PubChem Compound ID
121917
PubChem Substance ID
29302409, 32705138, 50070823, 78318963, 104414589, 129462946, 172649190, 224903230, 229472831, 234643315
Target and Pathway
Target(s) Xanthine dehydrogenase/oxidase Target Info Inhibitor [526237], [551871]
BioCyc Pathway Purine nucleotides degradation
Urate biosynthesis/inosine 5'-phosphate degradation
Guanosine nucleotides degradation
Adenosine nucleotides degradation
Retinoate biosynthesis II
KEGG Pathway Purine metabolism
Caffeine metabolism
Drug metabolism - other enzymes
Metabolic pathways
Peroxisome
PANTHER Pathway Adenine and hypoxanthine salvage pathway
Purine metabolism
PathWhiz Pathway Caffeine Metabolism
Purine Metabolism
Reactome Purine catabolism
WikiPathways Oxidative Stress
Effects of Nitric Oxide
Metabolism of nucleotides
Selenium Micronutrient Network
References
Ref 545270Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800002649)
Ref 526237Enantioselective uptake of BOF-4272, a xanthine oxidase inhibitor with a chiral sulfoxide, by isolated rat hepatocytes. Yakugaku Zasshi. 2001 Dec;121(12):989-94.
Ref 551871Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015

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