Drug Information

Drug General Information
Drug ID
D0B5MU
Former ID
DNC011229
Drug Name
SB-207710
Drug Type
Small molecular drug
Indication Discovery agent Investigative [539661]
Formula
C19H27IN2O4
InChI
InChI=1S/C19H27IN2O4/c1-2-3-6-22-7-4-13(5-8-22)12-26-19(23)14-11-15(20)16(21)18-17(14)24-9-10-25-18/h11,13H,2-10,12,21H2,1H3
InChIKey
FCKKCDRMGKXQDK-UHFFFAOYSA-N
PubChem Compound ID
5311423
PubChem Substance ID
7980566, 11056494, 14809756, 39341099, 53219391, 57359474, 85216152, 103341399, 114156055, 123106973, 127826302, 134348434, 135650986, 139521394, 179293978, 229002534
Target and Pathway
Target(s) 5-hydroxytryptamine 4 receptor Target Info Inhibitor [531144]
KEGG Pathway Calcium signaling pathway
cAMP signaling pathway
Neuroactive ligand-receptor interaction
Serotonergic synapse
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
5HT4 type receptor mediated signaling pathway
PathWhiz Pathway Excitatory Neural Signalling Through 5-HTR 4 and Serotonin
Reactome Serotonin receptors
G alpha (s) signalling events
WikiPathways Serotonin Receptor 4/6/7 and NR3C Signaling
Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signaling
References
Ref 539661(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 257).
Ref 531144J Med Chem. 2010 Oct 14;53(19):7035-47.Synthesis, structure-affinity relationships, and radiolabeling of selective high-affinity 5-HT4 receptor ligands as prospective imaging probes for positron emission tomography.

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