Drug Information

Drug General Information
Drug ID
D0B5AG
Former ID
DNC009206
Drug Name
Cis-3-phenoxy-2,3-dihydro-1H-inden-1-amine
Drug Type
Small molecular drug
Indication Discovery agent Investigative [529530]
Formula
C15H15NO
Canonical SMILES
C1C(C2=CC=CC=C2C1OC3=CC=CC=C3)N
InChI
1S/C15H15NO/c16-14-10-15(13-9-5-4-8-12(13)14)17-11-6-2-1-3-7-11/h1-9,14-15H,10,16H2/t14-,15+/m1/s1
InChIKey
AFPFOKAYUJMERG-CABCVRRESA-N
PubChem Compound ID
44560576
Target and Pathway
Target(s) Sodium-dependent noradrenaline transporter Target Info Inhibitor [529530]
Sodium-dependent dopamine transporter Target Info Inhibitor [529530]
KEGG Pathway Dopaminergic synapse
Parkinson's disease
Cocaine addiction
Amphetamine addiction
Alcoholism
PANTHER Pathway Adrenaline and noradrenaline biosynthesisP00001:Adrenaline and noradrenaline biosynthesis
Parkinson disease
Dopamine receptor mediated signaling pathway
Pathway Interaction Database Alpha-synuclein signaling
Reactome Na+/Cl- dependent neurotransmitter transportersR-HSA-442660:Na+/Cl- dependent neurotransmitter transporters
WikiPathways Monoamine Transport
NRF2 pathway
Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compoundsWP727:Monoamine Transport
Dopaminergic Neurogenesis
Parkinsons Disease Pathway
Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds
Neurotransmitter Clearance In The Synaptic Cleft
References
Ref 529530Bioorg Med Chem Lett. 2008 Jul 15;18(14):4224-7. Epub 2008 May 20.Discovery of a potent, selective, and less flexible selective norepinephrine reuptake inhibitor (sNRI).
Ref 529530Bioorg Med Chem Lett. 2008 Jul 15;18(14):4224-7. Epub 2008 May 20.Discovery of a potent, selective, and less flexible selective norepinephrine reuptake inhibitor (sNRI).

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