Drug Information

Drug General Information
Drug ID
D0B3PC
Former ID
DIB021107
Drug Name
UCB35625
Synonyms
UCB 35625; UCB-35625
Drug Type
Small molecular drug
Indication Discovery agent Investigative [540468]
Formula
C28H35Cl2N2O2+
InChI
InChI=1S/C28H34Cl2N2O2/c1-32(18-19-6-4-2-3-5-7-19)14-12-22(13-15-32)31-28(33)27-23-16-20(29)8-10-25(23)34-26-11-9-21(30)17-24(26)27/h8-11,16-17,19,22,27H,2-7,12-15,18H2,1H3/p+1
InChIKey
AHYGVFSLUXGXSH-UHFFFAOYSA-O
PubChem Compound ID
458342
PubChem Substance ID
607763, 7979263, 50905218, 57405491, 109723867, 178100515, 246412766
Target and Pathway
Target(s) CC chemokine receptor Target Info Antagonist [525795]
KEGG Pathway Cytokine-cytokine receptor interaction
Chemokine signaling pathway
Reactome Beta defensins
Binding and entry of HIV virion
Chemokine receptors bind chemokines
G alpha (i) signalling events
WikiPathways GPCRs, Class A Rhodopsin-like
Peptide GPCRs
GPCR ligand binding
GPCR downstream signaling
References
Ref 540468(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 3536).
Ref 525795A small molecule antagonist of chemokine receptors CCR1 and CCR3. Potent inhibition of eosinophil function and CCR3-mediated HIV-1 entry. J Biol Chem. 2000 Aug 25;275(34):25985-92.

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