Drug Information

Drug General Information
Drug ID
D0B1PD
Former ID
DIB006129
Drug Name
NPC-16377
Drug Type
Small molecular drug
Indication Psychotic disorders [ICD9: 290-299; ICD10:F20-F29] Terminated [545059]
Company
Scios Inc
Formula
C27H34ClNO4
Canonical SMILES
c1(c(oc2c(c1=O)cc(cc2)OCCCCCCN1CCC(CC1)O)c1ccccc1)C.Cl
CAS Number
CAS 139652-86-1
PubChem Compound ID
9890958
Target and Pathway
Target(s) Sigma(1)-type opioid receptor Target Info Modulator [526642], [532713], [533992]
WikiPathways miR-targeted genes in squamous cell - TarBase
miR-targeted genes in lymphocytes - TarBase
References
Ref 545059Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800001997)
Ref 526642Dextromethorphan antagonizes the acute depletion of brain serotonin by p-chloroamphetamine and H75/12 in rats. Brain Res. 1992 Oct 30;594(2):323-6.
Ref 532713Antitussives and substance abuse. Subst Abuse Rehabil. 2013 Nov 6;4:75-82.
Ref 533992Effects of the selective sigma receptor ligand, 6-[6-(4-hydroxypiperidinyl)hexyloxy]-3-methylflavone (NPC 16377), on behavioral and toxic effects of cocaine. J Pharmacol Exp Ther. 1993 Aug;266(2):473-82.

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