Drug Information

Drug General Information
Drug ID
D0B1KT
Former ID
DIB018761
Drug Name
AF353
Synonyms
AF-353; AF 353
Drug Type
Small molecular drug
Indication Discovery agent Investigative [467469]
Formula
C14H17IN4O2
InChI
InChI=1S/C14H17IN4O2/c1-7(2)8-4-11(20-3)9(15)5-10(8)21-12-6-18-14(17)19-13(12)16/h4-7H,1-3H3,(H4,16,17,18,19)
InChIKey
AATPYXMXFBBKFO-UHFFFAOYSA-N
PubChem Compound ID
15953802
PubChem Substance ID
22425373, 26559730, 33336708, 103612778, 104108644, 125646956, 131328439, 137548780, 162660567, 172918128, 178100947, 223968401, 227699018, 246650854
Target and Pathway
Target(s) P2X purinoceptor 3 Target Info Antagonist [531000]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
References
Ref 467469(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4125).
Ref 531000AF-353, a novel, potent and orally bioavailable P2X3/P2X2/3 receptor antagonist. Br J Pharmacol. 2010 Jul;160(6):1387-98.

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