Drug Information

Drug General Information
Drug ID
D0B0PP
Former ID
DNC010219
Drug Name
3,3-diphenylpropan-1-amine
Drug Type
Small molecular drug
Indication Discovery agent Investigative [530331]
Formula
C15H17N
Canonical SMILES
C1=CC=C(C=C1)C(CCN)C2=CC=CC=C2
InChI
1S/C15H17N/c16-12-11-15(13-7-3-1-4-8-13)14-9-5-2-6-10-14/h1-10,15H,11-12,16H2
InChIKey
KISZTEOELCMZPY-UHFFFAOYSA-N
PubChem Compound ID
79698
Target and Pathway
Target(s) Histamine H1 receptor Target Info Inhibitor [530331]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Inflammatory mediator regulation of TRP channels
PANTHER Pathway Histamine H1 receptor mediated signaling pathway
Reactome Histamine receptors
G alpha (q) signalling events
WikiPathways Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
IL-4 Signaling Pathway
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR ligand binding
GPCR downstream signaling
References
Ref 530331Bioorg Med Chem. 2009 Sep 15;17(18):6496-504. Epub 2009 Aug 13.Synthesis, structure-affinity relationships, and modeling of AMDA analogs at 5-HT2A and H1 receptors: structural factors contributing to selectivity.
Ref 530331Bioorg Med Chem. 2009 Sep 15;17(18):6496-504. Epub 2009 Aug 13.Synthesis, structure-affinity relationships, and modeling of AMDA analogs at 5-HT2A and H1 receptors: structural factors contributing to selectivity.

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