Drug Information

Drug General Information
Drug ID
D0AX0K
Former ID
DIB021099
Drug Name
U101958
Synonyms
U-101958; U 101958
Drug Type
Small molecular drug
Indication Discovery agent Investigative [541101]
Formula
C21H29N3O
InChI
InChI=1S/C21H29N3O/c1-17(2)25-20-10-7-13-22-21(20)23(3)19-11-14-24(15-12-19)16-18-8-5-4-6-9-18/h4-10,13,17,19H,11-12,14-16H2,1-3H3
InChIKey
WFLHEXUTTRRXFJ-UHFFFAOYSA-N
PubChem Compound ID
5615
PubChem Substance ID
4300765, 8153458, 11111944, 14777932, 29224653, 48259479, 50111286, 50266230, 90340683, 103831313, 103964997, 104309746, 117535804, 124750375, 124881781, 125693574, 129573846, 135089081, 142282997, 143160222, 178102406, 233921882, 242091380
Target and Pathway
Target(s) D(4) dopamine receptor Target Info Antagonist [534357]
KEGG Pathway Neuroactive ligand-receptor interaction
Dopaminergic synapse
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Dopamine receptor mediated signaling pathway
Nicotine pharmacodynamics pathway
Reactome Dopamine receptors
G alpha (i) signalling events
WikiPathways Hypothetical Network for Drug Addiction
Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
Genes and (Common) Pathways Underlying Drug Addiction
GPCR ligand binding
GPCR downstream signaling
Nicotine Activity on Dopaminergic Neurons
GPCRs, Other
References
Ref 541101(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5781).
Ref 534357Substituted 4-aminopiperidines having high in vitro affinity and selectivity for the cloned human dopamine D4 receptor. Eur J Pharmacol. 1997 Mar 19;322(2-3):283-6.

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