Drug Information

Drug General Information
Drug ID
D0AL3O
Former ID
DIB009483
Drug Name
VX-366
Synonyms
Isobutyramide; Isobutyramide, Vertex
Indication Hematopoietic [ICD10:D50-D89] Discontinued in Phase 2 [546039]
Company
Vertex Pharmaceuticals Inc
Canonical SMILES
C(=O)(N)C(C)C
CAS Number
CAS 563-83-7
Target and Pathway
Target(s) Hemoglobin Target Info Inhibitor [525637]
KEGG Pathway African trypanosomiasis
Malaria
Reactome Erythrocytes take up carbon dioxide and release oxygen
Erythrocytes take up oxygen and release carbon dioxide
Scavenging of heme from plasma
WikiPathways Binding and Uptake of Ligands by Scavenger Receptors
Uptake of Carbon Dioxide and Release of Oxygen by Erythrocytes
Uptake of Oxygen and Release of Carbon Dioxide by Erythrocytes
Factors involved in megakaryocyte development and platelet production
Folate Metabolism
Vitamin B12 Metabolism
Selenium Micronutrient Network
References
Ref 546039Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800006007)
Ref 525637A combination of hydroxyurea and isobutyramide to induce fetal hemoglobin in transgenic mice is more hematotoxic than the individual agents. Blood Cells Mol Dis. 1999 Jun-Aug;25(3-4):255-69.

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