Drug Information

Drug General Information
Drug ID
D0A7JH
Former ID
DIB004285
Drug Name
WY-50295-tromethamine
Synonyms
WY-50295T; Wy-49232
Drug Type
Small molecular drug
Indication Asthma [ICD10:J45] Phase 2 [525487]
Company
Wyeth-Ayerst Pharmaceuticals Inc
Formula
C27H30N2O6
Canonical SMILES
n1c2c(ccc1COc1cc3c(cc([C@@H](C(=O)O)C)cc3)cc1)cccc2
CAS Number
CAS 123016-21-7
PubChem Compound ID
44149608
Target and Pathway
Target(s) Arachidonate 5-lipoxygenase Target Info Inhibitor [525487]
BioCyc Pathway Aspirin-triggered lipoxin biosynthesis
Resolvin D biosynthesis
Leukotriene biosynthesis
Lipoxin biosynthesis
Aspirin triggered resolvin D biosynthesis
Aspirin triggered resolvin E biosynthesis
KEGG Pathway Arachidonic acid metabolism
Metabolic pathways
Serotonergic synapse
Ovarian steroidogenesis
Toxoplasmosis
NetPath Pathway IL4 Signaling Pathway
PathWhiz Pathway Arachidonic Acid Metabolism
WikiPathways Vitamin D Receptor Pathway
Arachidonic acid metabolism
Eicosanoid Synthesis
Selenium Micronutrient Network
References
Ref 525487WY-50295 tromethamine: a 5-lipoxygenase inhibitor without activity in human whole blood. Prostaglandins Leukot Essent Fatty Acids. 1999 Jan;60(1):31-41.
Ref 525487WY-50295 tromethamine: a 5-lipoxygenase inhibitor without activity in human whole blood. Prostaglandins Leukot Essent Fatty Acids. 1999 Jan;60(1):31-41.

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