Drug Information

Drug General Information
Drug ID
D0A5ZF
Former ID
DNC010138
Drug Name
3,3-Diethyl-1-(pyridin-3-yl)azetidine-2,4-dione
Drug Type
Small molecular drug
Indication Discovery agent Investigative [530511]
Formula
C12H14N2O2
Canonical SMILES
CCC1(C(=O)N(C1=O)C2=CN=CC=C2)CC
InChI
1S/C12H14N2O2/c1-3-12(4-2)10(15)14(11(12)16)9-6-5-7-13-8-9/h5-8H,3-4H2,1-2H3
InChIKey
OHEZXQVPDSACCJ-UHFFFAOYSA-N
PubChem Compound ID
44626811
Target and Pathway
Target(s) Leukocyte elastase Target Info Inhibitor [530511]
KEGG Pathway Transcriptional misregulation in cancer
Systemic lupus erythematosus
Pathway Interaction Database Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
C-MYB transcription factor network
Reactome Collagen degradation
Degradation of the extracellular matrix
Activation of Matrix Metalloproteinases
WikiPathways Hair Follicle Development: Cytodifferentiation (Part 3 of 3)
Human Complement System
Degradation of collagen
References
Ref 530511J Med Chem. 2010 Jan 14;53(1):241-53.4-Oxo-beta-lactams (azetidine-2,4-diones) are potent and selective inhibitors of human leukocyte elastase.
Ref 530511J Med Chem. 2010 Jan 14;53(1):241-53.4-Oxo-beta-lactams (azetidine-2,4-diones) are potent and selective inhibitors of human leukocyte elastase.

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