Drug Information

Drug General Information
Drug ID
D0A5XB
Former ID
DNC004642
Drug Name
Sulfamic acid benzo[1,3]dioxol-2-ylmethyl ester
Drug Type
Small molecular drug
Indication Discovery agent Investigative [527479]
Formula
C8H9NO5S
Canonical SMILES
C1=CC=C2C(=C1)OC(O2)COS(=O)(=O)N
InChI
1S/C8H9NO5S/c9-15(10,11)12-5-8-13-6-3-1-2-4-7(6)14-8/h1-4,8H,5H2,(H2,9,10,11)
InChIKey
UAXDMVNWVLYKAY-UHFFFAOYSA-N
PubChem Compound ID
11264735
Target and Pathway
Target(s) Carbonic anhydrase II Target Info Inhibitor [527479]
KEGG Pathway Nitrogen metabolism
Proximal tubule bicarbonate reclamation
Collecting duct acid secretion
Gastric acid secretion
Pancreatic secretion
Bile secretion
NetPath Pathway IL4 Signaling Pathway
EGFR1 Signaling Pathway
Reactome Erythrocytes take up carbon dioxide and release oxygen
Erythrocytes take up oxygen and release carbon dioxide
Reversible hydration of carbon dioxide
WikiPathways Reversible Hydration of Carbon Dioxide
Uptake of Carbon Dioxide and Release of Oxygen by Erythrocytes
Uptake of Oxygen and Release of Carbon Dioxide by Erythrocytes
References
Ref 527479J Med Chem. 2005 Mar 24;48(6):1941-7.Comparison of sulfamate and sulfamide groups for the inhibition of carbonic anhydrase-II by using topiramate as a structural platform.
Ref 527479J Med Chem. 2005 Mar 24;48(6):1941-7.Comparison of sulfamate and sulfamide groups for the inhibition of carbonic anhydrase-II by using topiramate as a structural platform.

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