Drug Information

Drug General Information
Drug ID
D0A2KN
Former ID
DIB018161
Drug Name
[125I]L750667
Synonyms
[125I]-L750667
Drug Type
Small molecular drug
Indication Discovery agent Investigative [540255]
Formula
C18H19IN4
InChI
InChI=1S/C18H19IN4/c19-15-3-5-16(6-4-15)23-10-8-22(9-11-23)13-14-12-21-18-17(14)2-1-7-20-18/h1-7,12H,8-11,13H2,(H,20,21)/i19-2
InChIKey
OOEUHRGMLFVKQO-GBVACIEGSA-N
PubChem Compound ID
5311214
PubChem Substance ID
7979709, 11056345, 16162037, 39340922, 57359392, 75183095, 114155565, 178100332
Target and Pathway
Target(s) D(4) dopamine receptor Target Info Antagonist [534293]
KEGG Pathway Neuroactive ligand-receptor interaction
Dopaminergic synapse
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Dopamine receptor mediated signaling pathway
Nicotine pharmacodynamics pathway
Reactome Dopamine receptors
G alpha (i) signalling events
WikiPathways Hypothetical Network for Drug Addiction
Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
Genes and (Common) Pathways Underlying Drug Addiction
GPCR ligand binding
GPCR downstream signaling
Nicotine Activity on Dopaminergic Neurons
GPCRs, Other
References
Ref 540255(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 3295).
Ref 534293Identification and pharmacological characterization of [125I]L-750,667, a novel radioligand for the dopamine D4 receptor. Mol Pharmacol. 1996 Dec;50(6):1658-64.

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