Drug Information

Drug General Information
Drug ID
D0A2IH
Former ID
DIB013879
Drug Name
KU-1257
Drug Type
Small molecular drug
Indication Duodenal ulcers [ICD10:K25-K27] Discontinued in Phase 3 [545005]
Company
Kyorin Pharmaceutical Co Ltd
Formula
C18H29N3O2
Canonical SMILES
C(=O)(NCCCOc1cc(CN2CCCCC2)ccc1)NCC
CAS Number
CAS 120958-90-9
PubChem Compound ID
129319
Target and Pathway
Target(s) Histamine H2 receptor Target Info Antagonist [533888]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Gastric acid secretion
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Histamine H2 receptor mediated signaling pathway
PathWhiz Pathway Intracellular Signalling Through Histamine H2 Receptor and Histamine
Gastric Acid Production
Reactome Histamine receptors
G alpha (s) signalling events
WikiPathways Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
Secretion of Hydrochloric Acid in Parietal Cells
GPCR ligand binding
GPCR downstream signaling
References
Ref 545005Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800001852)
Ref 533888Pharmacological profiles of the new histamine H2-receptor antagonist N-ethyl-N'-[3-[3-(piperidinomethyl)phenoxy] propyl] urea. Arzneimittelforschung. 1993 Feb;43(2):129-33.

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