Drug Information

Drug General Information
Drug ID
D0A0LE
Former ID
DNC013305
Drug Name
3-(2-methylbenzo[d]thiazol-5-yl)benzonitrile
Drug Type
Small molecular drug
Indication Discovery agent Investigative [528793]
Formula
C15H10N2S
Canonical SMILES
CC1=NC2=C(S1)C=CC(=C2)C3=CC=CC(=C3)C#N
InChI
1S/C15H10N2S/c1-10-17-14-8-13(5-6-15(14)18-10)12-4-2-3-11(7-12)9-16/h2-8H,1H3
InChIKey
QCTQEXSACACMOJ-UHFFFAOYSA-N
PubChem Compound ID
44427389
Target and Pathway
Target(s) Metabotropic glutamate receptor 5 Target Info Inhibitor [528793]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Gap junction
Long-term potentiation
Retrograde endocannabinoid signaling
Glutamatergic synapse
Huntington's disease
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Metabotropic glutamate receptor group III pathway
Metabotropic glutamate receptor group I pathway
Endogenous cannabinoid signaling
Reactome G alpha (q) signalling events
Class C/3 (Metabotropic glutamate/pheromone receptors)
WikiPathways Hypothetical Network for Drug Addiction
GPCRs, Class C Metabotropic glutamate, pheromone
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR ligand binding
GPCR downstream signaling
References
Ref 528793Bioorg Med Chem Lett. 2007 Jun 1;17(11):2987-91. Epub 2007 Mar 24.Discovery of heterobicyclic templates for novel metabotropic glutamate receptor subtype 5 antagonists.
Ref 528793Bioorg Med Chem Lett. 2007 Jun 1;17(11):2987-91. Epub 2007 Mar 24.Discovery of heterobicyclic templates for novel metabotropic glutamate receptor subtype 5 antagonists.

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